Anthranilamides with heteroarylsulfonyl side chain, process...

Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

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C514S311000, C514S312000, C514S397000, C514S445000, C514S235500, C514S380000, C514S347000, C546S153000, C546S293000, C548S312100, C548S243000, C544S405000, C549S065000

Reexamination Certificate

active

06903216

ABSTRACT:
This invention encompasses anthranilamides with heteroarylsulfonyl side chain, process for their preparation, their use as medicament or diagnostic aid, and pharmaceutical preparations containing them. Compounds of formula I,in which R1 to R7 have the meanings stated in the claims, act on the Kv1.5 potassium channel and inhibit a potassium current which is referred to as the ultra-rapidly activating delayed rectifier in the atrium of the human heart. They are therefore suitable as novel antiarrhythmic ingredients, such as for the treatment and prophylaxis of atrial arrhythmias, e.g. atrial fibrillation (AF) or atrial flutter.

REFERENCES:
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patent: 6531495 (2003-03-01), Brendel et al.
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patent: 0 686 625 (1995-12-01), None
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patent: WO 96/25936 (1996-08-01), None
patent: WO 98/04521 (1998-02-01), None
patent: WO 98/18475 (1998-05-01), None
patent: WO 98/18476 (1998-05-01), None
patent: WO 00/02851 (2000-01-01), None
patent: WO 00/78145 (2000-12-01), None

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