Anthranilamides and methods of their use

Details Anthranilamides and methods of their use Anthranilamides and methods of their use

2007-06-26

2007-06-26

Kumar, Shailendra (Department: 1621)

Organic compounds -- part of the class 532-570 series

Organic compounds

Amino nitrogen containing

C564S092000, C546S172000, C546S265000, C546S283400, C546S333000, C546S334000, C548S204000, C548S309700, C548S336100, C548S375100, C549S493000, C514S604000, C514S461000, C514S427000, C514S406000, C514S399000, C514S394000, C514S365000, C514S336000, C514S332000, C514S311000, C514S307000, C514S357000

Reexamination Certificate

active

10132163

ABSTRACT:
The present invention is related to anthranilamides of formula I,in which R(1) to R(7) have the meanings indicated herein, a process for their preparation, their use as medicaments, and pharmaceutical preparations containing them. The compounds act on the Kv1.5 potassium channel and inhibit a potassium current which is referred to as the ultra-rapidly activating delayed rectifier in the atrium of the human heart. The compounds are therefore suitable for use as novel antiarrhythmic agents for the treatment and prophylaxis of atrial arrhythmias (e.g., atrial fibrillation (AF) or atrial flutter).

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