Anthranilamide inhibitors of Aurora kinase

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

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Details

C544S295000

Reexamination Certificate

active

07625903

ABSTRACT:
The present invention relates to a compound represented by the following formula:or a pharmaceutically acceptable salt thereof;where R1, R2, R3, R4, r and s are as previously defined. Compounds of the present invention are useful in the treatment of diseases associated with Aurora kinase activity such as cancer.

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Cheethem, et al, “Crystal Structure of Aurora-2, an Oncogenic serine/Threonine Kinase.”Journal of Biological Chemistry., Nov. 8, 2002: 277:42419-42422: pp. 44420-44421, Fig 1 and 2.

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