Drug – bio-affecting and body treating compositions – Conjugate or complex of monoclonal or polyclonal antibody,... – Conjugated via claimed linking group – bond – chelating agent,...
Patent
1980-05-21
1982-05-11
Brown, Johnnie R.
Drug, bio-affecting and body treating compositions
Conjugate or complex of monoclonal or polyclonal antibody,...
Conjugated via claimed linking group, bond, chelating agent,...
424181, 435 78, 536 64, 260365, A61K 3171, C07H 1526
Patent
active
043293395
ABSTRACT:
There is disclosed compounds of the formula ##STR1## wherein R.sup.1 represents a methyl or acetonyl group and R.sup.2 represents a hydrogen atom, a hydroxyl group or a group of the formula ##STR2## and a process for the preparation thereof. The compounds are useful as intermediates for the preparation of anthracycline antibiotics and certain of the compounds exhibit per se activity as antibacterial and antitumor agents.
REFERENCES:
patent: 3988315 (1976-10-01), Umezawa et al.
Asheshov et al., "Biochem. Jour.", 81, 1961, pp. 101-104.
Oki et al., "The Jour. of Antibiotics", vol. 28, 1975, pp. 830-834.
Fujiwara Akiko
Hoshino Tatsuo
Tazoe Masaaki
Brown Johnnie R.
Hoffman Frank P.
Hoffmann-La Roche Inc.
Leon Bernard S.
Saxe Jon S.
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