Anthracyclinone glycosides containing an n-oxidized sugar

Details Anthracyclinone glycosides containing an n-oxidized sugar Anthracyclinone glycosides containing an n-oxidized sugar

1990-01-08

1991-08-06

Peselev, Elli

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

C07H 1524

Patent

active

050379712

ABSTRACT:
The present invention relates to anthracycline derivatives of the formula I ##STR1## in which at least one of the two substitutents R.sub.1 and R.sub.2 represents an N-oxidized sugar or an N-oxidized sugar combination, and a chemical process for the preparation of these compounds and their use as medicaments for the treatment of malignant tumors.

REFERENCES:
patent: 3928387 (1975-12-01), Kierstead et al.
patent: 4316011 (1982-02-01), Oki et al.
patent: 4734493 (1988-03-01), Yoshimoto et al.
patent: 4737583 (1988-04-01), Huber et al.
patent: 4795808 (1989-01-01), Berscherd et al.
"The Megalomicins. I. D-Rhodosamine, a New Dimethylamino Sugar," Journal of the Amer. Chem. Society, pp. 7505-7506, A. K. Mallams, vol. 91, No. 26 (1969).

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