Anthracyclinone derivatives and their use in amyloidosis

Organic compounds -- part of the class 532-570 series – Organic compounds – Four or more ring nitrogens in the bicyclo ring system

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544380, 546195, 546285, 548528, C07D295108

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active

060968885

ABSTRACT:
The present invention provides the new use in the treatment of amyloidosis with the anthracyclinone of formula (A) wherein R1, R2, R3, R4, and R5, are appropriate substituents. Some compounds of formula (A) are novel. Processes for their preparation and pharmaceutical composition containing them are also described.

REFERENCES:
patent: 5744454 (1998-04-01), Suarato et al.
Hartmann et al, Chemical Abstracts, vol. 126, No. 144,048 (1997).
Sumitomo, Chemical Abstracts, vol. 103, No. 141,751 (1985).
Povarov et al. Chemical Abstracts, vol. 91, No. 20926 (1979).

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