Anthracyclines

Details Anthracyclines Anthracyclines

1978-06-01

1980-04-01

Trousof, Natalie

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

424279, 260351, 260365, 560 56, 560 61, 568648, 568654, C07D30788

Patent

active

041961277

ABSTRACT:
There is provided a novel method of synthesizing certain heterocyclic quinones. In particular there is provided a novel and regiospecific synthesis of 9-acetyl-6,11-dihydroxy-4-methoxy-7,8,9,10-tetrahydronaphthacene-5,12-quin one (7,9-dideoxydaunomycinone) which is a known intermediate in the synthesis of daunomycinone. There is also provided a method of preparing analogs of 7,9-dideoxydaunomycinone which thus provide for the preparation of known and desired analogs of daunomycinone. Daunomycinone is a known compound which is an intermediate in the preparation of the clinically accepted naturally-occurring antitumor antibiotics daunomycin and its derivative adriamycin.

REFERENCES:
Kende et al., Tetrahedron Letters, No. 31, pp. 2935-2938, 1973.
Singh, E. et al., Chem. Abstracts, vol. 81, 65170x.

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