Anthracycline synthesis

Details Anthracycline synthesis Anthracycline synthesis

1978-05-22

1980-07-29

Douglas, Winston A.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

260351, 260364, 260376, 260369, C07C 8710, C07C 4974

Patent

active

042150620

ABSTRACT:
A process for synthesizing doxorubicin and related compounds from aloe-emodin is disclosed. Intermediates useful in the preparation of doxorubicin and related compounds are also disclosed.

REFERENCES:
patent: 3721684 (1973-03-01), Meyers et al.
patent: 4070382 (1978-01-01), Kende et al.
patent: 4132721 (1979-01-01), Bernardi et al.
Journal of the American Chemical Society, vol. 99, p. 5518, 1977, Kelly et al.
Tetrahedon Letters p. 2383, 1977, Raynolds et al.
Journal of American Chemical Society vol. 98, pp. 1967-1969, 1976, Kend et al.
Canadian Journal of Chemistry, vol. 51, p. 466; 1973, Wong et al.
Journal of Medicinal Chemistry, vol. 17, No. 6 p. 659, 1974 Acton et al.
Journal of the American Chemical Society vol. 97, No. 15, p. 4425, 1975 Kende et al.
Chemical Abstracts, vol. 43, #2985f, "Polycyclic aromatic amines", G. M. Badger 1948.
Chemical Abstracts vol. 73 #17076i, "Catalytic action of quinones in the oxidation of 4-methyl meso-benzanthrane to mesopenzanthrone-4-carboxylic acid", W. Bradley and Kitti Shah, 1959.

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