Anthracycline synthesis

Details Anthracycline synthesis Anthracycline synthesis

1982-01-18

1983-09-20

Trousof, Natalie

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

260383, 260384, C07C 5034, C07C 5016

Patent

active

044055226

ABSTRACT:
A synthesis of 5,12-dihydroxy-1,3,4-trihydro-2,6,11-tetracenetrione and its derivatives from leucoquinizarin or a derivative of leucoquinizarin. The tetracenetriones are well-known intermediates in the synthesis of compounds related to doxorubicin.

REFERENCES:
patent: 3019260 (1962-01-01), McCormick et al.
patent: 3201424 (1965-08-01), McCormick et al.
patent: 4021457 (1977-05-01), Kende et al.
patent: 4215062 (1980-07-01), Mitscher
Krohn et al., "Regio-und stereoselektive Synthese der .alpha.-, .beta.-und .gamma.-Rhodomycinone uber intramolekulare Marschalk-Cyclisierung", Chem. Ber., vol. 113, pp. 2994-3009, (1980).
Krohn et al., "Stereoselective Total Synthesis of Anthracyclinones", Chem. Ber., vol. 111(12), pp. 3823-3837, 1978.
Kende et al., "A Regiospecific Total Synthesis of (.+-.)-Daunomycinone", Tetrahedron Letters, No. 14, pp. 1201-1204, 1979.
Kende et al., "Total Synthesis of (.+-.)-Daunomycinone and (.+-.)-Carminomycinone", Journal of American Chemical Society, vol. 98, No. 7, pp. 1967-1969, 1976.

Affiliated with

Also associated with

Rating

Anthracycline synthesis does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Anthracycline synthesis, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Anthracycline synthesis will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-587097