Anthracycline glycosides, use and compositions containing same

Details Anthracycline glycosides, use and compositions containing same Anthracycline glycosides, use and compositions containing same

1984-06-18

1986-01-07

Brown, Jonnie R.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

536 64, A61K 3171, C07H 1524

Patent

active

045634440

ABSTRACT:
Anthracycline glycosides of the formula (I) ##STR1## wherein one of R.sub.1 and R.sub.2 is hydrogen and the other of R.sub.1 and R.sub.2 is hydroxy, each of R.sub.3, R.sub.4 and R.sub.5 is independently selected from the group consisting of hydrogen and hydroxy and X is hydrogen or trifluoroacetyl, with the provisos that R.sub.4 and R.sub.5 are not simultaneously hydroxy and that if R.sub.3 is hydroxy, then X is hydrogen, which are useful in treating certain mammalian tumors are prepared by condensing an aglycone of the formula (II) ##STR2## wherein R.sub.1 and R.sub.2 are defined as above, with a suitable protected halosugar, after which the protecting groups are removed.

REFERENCES:
patent: 4046878 (1977-09-01), Patelli et al.
patent: 4199571 (1980-04-01), Penco et al.
patent: 4247545 (1981-01-01), Cassinelli et al.
patent: 4355026 (1982-10-01), Umezawa et al.

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