Anthracycline glycosides, their preparation, use and composition

Details Anthracycline glycosides, their preparation, use and composition Anthracycline glycosides, their preparation, use and composition

1980-07-14

1982-03-30

Brown, Johnnie R.

Drug, bio-affecting and body treating compositions

Conjugate or complex of monoclonal or polyclonal antibody,...

Conjugated via claimed linking group, bond, chelating agent,...

536 17A, A61K 3171, C07H 1524

Patent

active

043224121

ABSTRACT:
There are disclosed compounds which exhibit anti-tumor activity. These compounds are of the formula I: ##STR1## wherein R.sub.1 is hydrogen, hydroxy or methoxy, R.sub.2 is hydrogen or hydroxy, and each of R.sub.3 and R.sub.4 independently is hydrogen or methyl, with the proviso that R.sub.3 and R.sub.4 are not simultaneously hydrogen, and pharmaceutically acceptable acid addition salts thereof. Also disclosed are processes for producing and using said compounds and therapeutic compositions containing same.

REFERENCES:
patent: 4039663 (1977-08-01), Arcamone et al.
patent: 4183919 (1980-01-01), Cassinelli et al.
patent: 4191756 (1980-03-01), Masi et al.
Arcamone et al., "Tetrahedron Letters", No. 30, pp. 3353-3356, 1968.

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