Anthracycline glycosides, their preparation and use

Details Anthracycline glycosides, their preparation and use Anthracycline glycosides, their preparation and use

1976-09-13

1978-01-10

Brown, Johnnie R.

Drug, bio-affecting and body treating compositions

Conjugate or complex of monoclonal or polyclonal antibody,...

Conjugated via claimed linking group, bond, chelating agent,...

536 4, 536 17, 536 18, 536 53, 536118, 536119, 536122, A61K 3170, C07H 1524

Patent

active

040679691

ABSTRACT:
The novel compounds, 4'-deoxy-daunomycin and 4'-deoxy-adriamycin, as well as derivatives thereof are useful as anti-tumor antibiotics. These compounds are prepared by condensing the corresponding aglycone with a novel trifluoracetyl protected reactive halo sugar which is 2,3,4,6-tetradeoxy-3-trifluoroacetamido-L-threo-hexopyranosyl chloride.

REFERENCES:
patent: 3697652 (1972-10-01), Rovati et al.
patent: 3803124 (1974-04-01), Arcamone et al.
patent: 4020270 (1977-04-01), Arcamone et al.

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