Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Patent
1983-09-26
1985-07-02
Brown, Johnnie R.
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
260365, C07H 1524
Patent
active
045269602
ABSTRACT:
This invention relates to compounds of the formula ##STR1## wherein R is a hydrogen atom, a lower alkyl, aryl or aryl-(lower alkyl) group, a 5-membered or 6-membered heteroaromatic group in which the hetero atom is nitrogen, oxygen or sulphur or a group of the formula ##STR2## wherein R' is a hydroxy, lower alkoxy, amino, lower alkylamino, di-(lower alkyl)amino or arylamino group, n stands for an integer of 1 to 4, n' stands for an integer of 2 to 10, R.sup.1 and R.sup.2 each are a hydrogen atom or one of R.sup.1 and R.sup.2 is a hydrogen atom and the other is a hydroxy, lower alkoxy or benzyloxy group and X is a group of the formula ##STR3## and pharmaceutically acceptable acid addition salts thereof, a process for their manufacture and medicaments containing them. These compounds and salts possess antitumor activity.
REFERENCES:
patent: 4125709 (1978-11-01), Smith
patent: 4183919 (1980-01-01), Cassinelli et al.
patent: 4263428 (1981-04-01), Apple et al.
patent: 4275192 (1981-06-01), Apple et al.
patent: 4393052 (1983-07-01), Bargiotti et al.
Matsuzawa et al., "The Journal of Antibiotics", vol. XXXIV, No. 12, Dec. 1981, pp. 1596-1607.
Broadhurst Michael J.
Hassall Cedric H.
Thomas Gareth J.
Brown Johnnie R.
Hoffman Frank P.
Hoffmann-La Roche Inc.
Leon Bernard S.
Saxe Jon S.
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