Anthracycline glycoside derivatives

Details Anthracycline glycoside derivatives Anthracycline glycoside derivatives

1990-10-22

1993-06-15

Brown, Johnnie R.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

514 34, C07H 1524

Patent

active

052200019

ABSTRACT:
A compound of the following formula (I) exhibits an excellent antitumor activity ##STR1## wherein R.sub.1 and R.sub.2 represent hydrogen atom, respectively, or include both straight or branch chain alkylidene group of 1-10 carbon atoms; R.sub.3 represents hydrogen atoms, straight and branch chain alkyl group of 1-10 carbon atoms, straight or branch chain alkyloxycarbonyl group of 1-10 carbon atoms or 3-membered to 6-membered heterocycle containing one nitrogen atom with adjacent alkylene group such as pyrrolidine and N-butoxycarbonyl-pyrrolidine; R.sub.4 and R.sub.5 represent hydrogen atom or alkyl group of 1-5 carbon atoms, respectively; and n represents 0 or an integer of 1-10, or pharmaceutically acceptable salt thereof.

REFERENCES:
patent: 3590028 (1971-06-01), Arcamone et al.
patent: 3997662 (1976-12-01), Pinnert et al.
patent: 4870058 (1989-09-01), Morton et al.

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