Anthracycline glycoside compositions, their use and preparation

Details Anthracycline glycoside compositions, their use and preparation Anthracycline glycoside compositions, their use and preparation

1981-04-27

1983-12-06

Brown, Johnnie R.

Drug, bio-affecting and body treating compositions

Conjugate or complex of monoclonal or polyclonal antibody,...

Conjugated via claimed linking group, bond, chelating agent,...

424177, 424182, 536 64, 536 5, A61K 3170, C07H 1708

Patent

active

044193483

ABSTRACT:
Anthracycline glycoside antibiotics are complexed with cardiolipin and then encapsulated in liposomes to reduce mammalian cardiac tissue uptake of the anthracycline glycoside and to thereby reduce the deleterious effect of such cardiac tissue uptake. The invention is directed to the composition, preparation and use of the encapsulated complex of anthracycline glycoside.

REFERENCES:
patent: 3993754 (1976-11-01), Rahman et al.
patent: 4256632 (1981-03-01), Levin et al.
patent: 4263428 (1981-04-01), Apple et al.

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