Drug – bio-affecting and body treating compositions – Conjugate or complex of monoclonal or polyclonal antibody,... – Conjugated via claimed linking group – bond – chelating agent,...
Patent
1977-07-22
1979-01-09
Brown, Johnnie R.
Drug, bio-affecting and body treating compositions
Conjugate or complex of monoclonal or polyclonal antibody,...
Conjugated via claimed linking group, bond, chelating agent,...
260365, 260376, 260380, 536 4, 536 17, A61K 3171, C07H 1524
Patent
active
041338774
ABSTRACT:
Novel antitumor antibiotics, which are daunomycin analogues of the formula: ##STR1## wherein R.sub.1 is hydrogen or a C.sub.1 -C.sub.4 lower alkyl, R.sub.2 is a C.sub.1 -C.sub.4 lower alkyl, a C.sub.3 -C.sub.6 cycloalkyl, phenyl, lower alkyl phenyl, lower alkoxy phenyl or halophenyl, and R.sub.3 is hydrogen or trifluoroacetyl are prepared by condensing 2,3,6-trideoxy-3-trifluoroacetamido-4-0-trifluoroacetyl-.alpha.-L-lyxopyra nosyl chloride with novel aglycones of the formula: ##STR2## which are in turn prepared by a novel method from 14-bromodaunomycinone through a series of novel intermediates.
REFERENCES:
patent: 4039663 (1977-08-01), Arcamone et al.
patent: 4058519 (1977-11-01), Arcamone et al.
Arcamone Federico
Bernardi Luigi
Giardino Pietro
Masi Paolo
Suarato Antonino
Brown Johnnie R.
Societa Farmaceutici Italia S.p.A.
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