Anthracycline derivatives having cytostatic activity

Details Anthracycline derivatives having cytostatic activity Anthracycline derivatives having cytostatic activity

1988-07-07

1990-04-03

Griffin, Ronald W.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 53, C07H 1524, C07G 3700

Patent

active

049141910

ABSTRACT:
The invention relates to new anthracycline derivatives having cytostatic activity and the general formula I ##STR1## in which the radicals R.sup.1 is hydrogen or a hydroxyl group, R.sup.2 is hydrogen or a hydroxyl group or a structure of the formula II, and R.sup.3 is a hydroxyl group or a structure of the formula II ##STR2## in which R.sup.4 is an aliphatic or aromatic acyl group, with the proviso that at least one of the radicals R.sup.2 and R.sup.3 has a structure of the formula II, which are optionally in the form of a salt of an inorganic or organic acid, as well as to the process for the preparation thereof, and to the use thereof in pharmaceuticals.

REFERENCES:
patent: 4039663 (1977-08-01), Arcamone et al.
patent: 4325946 (1982-04-01), Bargiotti et al.
patent: 4591637 (1986-05-01), Acton et al.
Brockmann et al., Tetrahedron Letters, No. 6, 1969, pp. 415-419, (and English language translation).
Ihn et al., The Journal of Antibiotics, vol. XXXIII, No. 12, 1980, pp. 1457-1461.
Fleck et al., Studia Biophisica, vol. 104, Nos. 1-3, 1984, pp. 215-218.

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