Anthracycline derivatives and their use as cytostatics

Details Anthracycline derivatives and their use as cytostatics Anthracycline derivatives and their use as cytostatics

1986-02-03

1987-12-15

Brown, J. R.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

536 64, A61K 3171, C07H 1524

Patent

active

047133716

ABSTRACT:
The present invention relates to the micro-organism Streptomyces purpurascens (DSM 2658), its mutants and variants, a process for the preparation of anthracycline derivatives by fermentation of these cultures and to the anthracycline derivatives themselves. The new compounds are distinguished by antibacterial activity and, in addition, they act against various types of tumors.

REFERENCES:
patent: 4316011 (1982-02-01), Oki et al.
patent: 4418192 (1983-11-01), Tanaka et al.
patent: 4439603 (1984-03-01), Umezawa et al.
Lin et al., J. Med. Chem., 1980, 23, 1242-1244.
Oki et al., The Journal of Antibiotics, vol. XXXIII, No. 11, (Nov. 1980), 1331-1340.
Brockmann et al., Tetrahedron Letters, No. 11, pp. 831-834, (1975).

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