Anthracycline derivatives and process for preparing the same

Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives

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424181, 435 78, A61K 3171, C07H 1524

Patent

active

042673127

ABSTRACT:
New anthracycline derivatives, 1-hydroxy-13-dihydrodaunomycin and N-formyl-1-hydroxy-13-dihydrodaunomycin are produced by microbial transformation of .epsilon.-pyrromycinone and .epsilon.-isorhodomycinone with daunomycin-producing streptomyces and their mutants. The derivatives herein are useful as cancer chemotherapeutic agents.

REFERENCES:
patent: 4039736 (1977-08-01), Nettleton, Jr. et al.
patent: 4146616 (1979-03-01), Penco et al.

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