Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
1999-07-27
2001-02-27
Rotman, Alan L. (Department: 1612)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C514S282000, C546S043000, C546S044000, C546S045000
Reexamination Certificate
active
06194422
ABSTRACT:
BACKGROUND OF THE INVENTION
1. Field of the Invention
The present invention relates to imino aza-anthracyclinone derivatives, their use for the treatment of amyloidoses, methods for their preparation and pharmaceutical compositions containing them.
2. Description of the Background
The relationship between amyloidosis, cell death and loss of tissue function appears to be of relevance for different type of disorders including some neurodegenerative disorders. Therefore, the prevention of amyloid formation and/or the induction of amyloid degradation can be an important therapeutic strategy for all pathological disorders associated with amyloidosis including peripheral amyloidoses and neurodegenerative disorders of the Alzheimer's type.
SUMMARY OF THE INVENTION
The present invention provides imino aza-anthracyclinones and their use in the treatment of amyloidoses. This new class of molecules is derived from a parent compound named anthrazalone that is characterized by the presence of an anthraquinone system fused to a bridged heterocyclic ring and whose structure is depicted below:
REFERENCES:
patent: 5731313 (1998-03-01), Suarato et al.
patent: 5985887 (1999-11-01), Caruso et al.
Bandiera Tiziano
Caruso Michele
Faiardi Daniela
Lansen Jacqueline
Suarato Antonino
Desai Rita
Oblon & Spivak, McClelland, Maier & Neustadt P.C.
Pharmacia & Upjohn SpA
Rotman Alan L.
LandOfFree
Anthracycline derivatives does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Anthracycline derivatives, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Anthracycline derivatives will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2576935