Anthracycline compounds and intermediates

Details Anthracycline compounds and intermediates Anthracycline compounds and intermediates

1992-05-06

1994-03-15

Brown, Johnnie R.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

546 77, 546 78, 552201, 552202, 552208, 552209, 552261, 552262, 552271, 552272, C07H 1524, C07D22118

Patent

active

052947017

ABSTRACT:
This invention provides novel anti-tumour compounds of the formula ##STR1## wherein R.sub.1 and R.sub.2 are hydrogen or together form an alkyl-, alkoxy- or OH-substituted aromatic group, which optionally contains an N atom as a hetero-atom; R is --COCH.sub.3 or --C.tbd.C--R.sub.4 and R.sub.4 is H or trimethylsilyl; and R.sub.3 is H or --COCF.sub.3 ; and acid addition salts thereof; as well as compositions containing these compounds.

REFERENCES:
patent: 4564674 (1986-01-01), Terashima et al.
patent: 4973674 (1990-11-01), Brasca et al.
patent: 5079349 (1992-01-01), Scheeren

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