Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Patent
1990-11-01
1993-03-23
Brown, Johnnie R.
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
514 34, C07H 1524
Patent
active
051965224
ABSTRACT:
The present invention is a compound having the structure ##STR1##
REFERENCES:
patent: 4035566 (1977-07-01), Israel et al.
patent: 4109076 (1978-08-01), Henry et al.
patent: 4301277 (1981-11-01), Acton et al.
patent: 4464529 (1984-08-01), Mosher et al.
patent: 4585859 (1986-04-01), Mosher et al.
patent: 4755619 (1988-07-01), Creighton et al.
patent: 4826964 (1989-05-01), Acton et al.
patent: 4841085 (1989-06-01), Farquhar et al.
patent: 4950738 (1990-08-01), King et al.
Tsuchiya, T. et al., Synthesis and Antitumor Activities of 14-O-Acyl Derivatives of 7-O-(2,6-Dideoxy-2-Fluoro-.alpha.-L-Talopyrangosyl) Adriamycinone, J. of Antibiotics (1988) XLI:988-991.
Griffith, W. P. et al., Preparation and Use of Tetra-n-butylammonium Perruthenate (TBAP Reagent) and Tetra-n-propylammonium Per-ruthenate (TPAP Reagent) as New Catalytic Oxidants for Alcohols, The Journal Chem. Soc., Chem. Commun., (9187) 1625-1627.
Acton, E. M. et al., N-(2-Hydroxyethyl)doxorubicin from Hydrolysis of 3'-Deamino-3'-(3-cyano-4-morpholinyl)doxorubicin, J. Med. Chem. (1986) 29:2120-2122.
Streeter, D. G. et al., Uptake and Retention of Morpholinyl Anthracyclines by Adriamycin-Sensitive and -Resistant P388 Cells, Cancer Chemother. Pharmacol., (1986) 16:247-252.
Sikic, B. I. et al., Dissociation of Antitumor Potency from Anthracycline Cardiotoxicity in a Doxorubicin Analog, Science (1985) 328:1544-1546.
Streeter, D. G. et al., Comparative Cytotoxicities of Various Morpholinyl Anthracyclines, Cancer Chemother. Pharmacol. (1985) 14:160-164.
Arcamone, F., Properties of Antitumor Anthracyclines and New Developments in Their Application: Cain Memorial Award Lecture, Cancer Research (1985) 45:5995-5999.
Acton, E. M. et al., Intensely Potent Morpholinyl Anthracyclines, J. Med. Chem. (1984) 27:638-645.
Horton, D. et al., 14-Esters of 7-O-(3,4-Di-O-Acetyl-2,6-Dideoxy-60 -L-Lyo-Hexopyranosyl)adriamycinone: Synthesis and Antitumor Activity, J. of Antibiotics (1983) XXXVI:1211-1215.
Johnston, J. B. et al., 3'-(3-Cyano-4-Morpholinyl)-3'-Deaminoadriamycin: A New Anthracycline With Intense Potency, Biochemical Pharmacology (1983) 32:3255-3258.
Acton, E. M. et al., Synthesis and Preliminary Antitumor Evaluation of 5-Iminodoxorubicin, J. Med. Chem. (1981) 24:669-673.
Tong, G. L. et al., Adriamycin Analogues. 3. Synthesis of N-Alkylated Anthracyclines With Enhanced Efficacy and Reduced Cardiotoxicity, J. Med. Chem. (1979) 22:912-918.
Corey, E. J. et al., Pyridinium Chlorochromate. An Efficient Reagent for Oxidation of Primary and Secondary Alcohols to Carbonyl Compounds, Tetrahedron Letters (1975) 31:2647-2650.
Fieser, L. F. et al., Reagents for Organic Synthesis (1967) 1:142-144.
Arcamone, F., Doxorubicin Anticancer Antibiotics, Academic press, (1981) 194-258.
Wang, Y. and Farquhar, D., Aldophosphamide Acetal Diacetate and Structural Analogues: Synthesis and Cytotoxicity Studies, J. Med. Chem. (1991) 34:197-203.
Acton, E. M. et al., Morpholinyl Anthracyclines in: Anthracycline and Anthracenedione-Based Anticancer Agents, William J. Lown; Ed., Elsevier Science Publishers: Amsterdam (1988) 55-101.
Muggia, F. M. et al., Anthracycline Antibiotics in Cancer Therapy, Martinus Nijhoff Publishers, 91982) 175-219.
Search of Dialog Information Services files 265, 399, 155, 350, 351, 340, 72 and 159.
Cherif Abdallah
Farquhar David
Board of Regents , The University of Texas System
Brown Johnnie R.
Peselev Elli
LandOfFree
Anthracycline analogues bearing latent alkylating substituents does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Anthracycline analogues bearing latent alkylating substituents, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Anthracycline analogues bearing latent alkylating substituents will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1352691