Anthracyclin derivatives

Details Anthracyclin derivatives Anthracyclin derivatives

1987-05-05

1988-04-12

Brown, J. R.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

C07H 1524

Patent

active

047375833

ABSTRACT:
The present invention relates to anthracyclin derivatives of the formula I ##STR1## in which R.sub.1 and R.sub.2 are identical or different and represent the sugar residue Roa (L--rhodosamine) of the formula ##STR2## or the sugar combination Roa--dF.dbd.CinB (dF=2-deoxy-L-fucose; CinB.dbd.L-cinerulose B) of the formula ##STR3## The invention furthermore relates to a process for the preparation of the above compounds of the formula I, and to their use as cytostatic agents.

REFERENCES:
patent: 4316011 (1982-02-01), Oki et al.
J. Antibiotics, vol. 36(5):83-65 (May 1983).
J. Antibiotics, vol. 29(12):76-116 (Dec. 1976).
J. Antibiotics, vol. 36(8):1080-1083 (Aug. 1983).
EP-A2-131 181 to Aretz et al (Hoechst A.G.).
EP-A1-0 110 115 to Umezawa et al. (Microbiology Chemistry Research Foundation).
Certified Translation of German Priority Document P 33 25 957.7.

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