Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1993-10-22
1995-09-05
Haley, Jacqueline
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514403, 5483565, A61K 31415, C07D23154
Patent
active
054479509
ABSTRACT:
Compounds of formula (I) ##STR1## in which R.sub.1 is A-N(O)R'R" and R.sub.2, R.sub.3 and R.sub.4 are each separately selected from hydrogen, X and NH-A-N(O)R'R" wherein X is hydroxy, halogeno, amino, C.sub.1-4 alkoxy or C.sub.2-18 alkanoyloxy, A is a C.sub.2-4 alkylene group with a chain length between N or NH and N(O)R'R" of at least 2 carbon atoms and R' and R" are each separately selected from C.sub.1-4 alkyl groups and C.sub.2-4 hydroxyalkyl and C.sub.3-4 dihydroxyalkyl groups in which the carbon atom attached to the nitrogen atom does not carry a hydroxy group and no carbon atom is substituted by two hydroxy groups, or R' and R" together are a C.sub.2-6 alkylene group which with the nitrogen atom to which R' and R" are attached forms a heterocyclic group having 3 to 7 atoms in the ring, and physiologically acceptable salts thereof are of value in the treatment of anaerobic bacterial infections.
REFERENCES:
patent: 3174994 (1965-03-01), Sutton
patent: 4686218 (1987-08-01), Marinis et al.
patent: 4963554 (1990-10-01), Combs et al.
A. Paul Krapcho et al. "Synthesis and antitumor evaluations of symmetrically and unsymmetrically substituted 1,4-Bis . . . " J. Med. Chem. 1991, 34, pp. 2373-2380.
J. Med. Chem., 1989, 24. Karzhendler et al. "Synthesis of aminoanthraquinone . . . ", pp. 23-30.
Stefenska, et al. "Synthesis of Unsymmetrically . . . " European J. Med. Chem., 1989 32, pp. 1724-1728.
Cheng et al. "The design synthesis . . . " Progress in Medicinal Chemistry, 1983, 20, pp. 83-118.
Fujiwara et al. "N-oxides and . . . " J. Het. Chem. 1969, 6, pp. 389-392.
Langendoen et al. "An approach to novel . . . " Tetrahedron, 1988, 44, pp. 3627-3631.
Langendoen et al. "Regiospecific C-9 substitution . . . " Terahedron, 1989, 45, pp. 1759-1762.
Brunston et al. "Alcaloides Des . . . " Photochemistry, 1972, 11, pp. 3073-3075.
Bild et al. "Notiz uber die . . . " Helvetica Chimica Acta, 1967, 50, pp. 1885-1892.
Jarman et al. "Analogues of tamoxifen . . . " Anti-Cancer Drug Design, 1986, 1 pp. 259-268.
Zeman et al. "SR-4233: A new bioreductive agent" Int. J. Radiation Oncology, Biol. Phys., 1986, 12, pp. 1239-1242.
Jenkins. "Hypoxia-selective agents . . . " The Chemistry of Antitumor Agents, Wilman (eds.), 1990, pp. 342-369.
Hulbert et al. "Hycanthone analogs . . . " Science, 1974, 186 pp. 647-648.
Connars. "Alkylating prodrugs in . . . " Structure-Activity Relationship of Anti-tumor Agents, 1983, pp. 47-57.
Wilson et al. "Bis-Bioreductive agents . . . " 7th Intl Conf. on Chem. Modifiers of Cancer Treatment, Florida, USA, Feb. 2-5, 1991, p. 248.
Proceedings, 83rd Annual Meeting of the American Association for Cancer Research, May 20-23, 1992, San Diego, Calif., USA, vol. 33, Mar. 1992.
NCI-EORTC symposium on new drugs in cancer therapy. Amsterdam, Mar. 17-20, 1992.
British Technology Group Limited
Haley Jacqueline
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