Anthelmintic pyridine and thiazole substituted benzimidazole car

Details Anthelmintic pyridine and thiazole substituted benzimidazole car Anthelmintic pyridine and thiazole substituted benzimidazole car

1975-08-07

1977-05-31

Rotman, Alan L.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

260295F, 260296R, 260297R, 260290HL, 260302R, 260302H, 424263, 424270, C07D23532

Patent

active

040269361

ABSTRACT:
Compounds represented by the formula ##STR1## wherein R is ##STR2## R.sup.1 is 2-pyridyl, 3-pyridyl, 4-pyridyl or 2-thiazyl, R.sup.2 is lower alkyl and n is 1 or 2,
And acid addition salts of the compounds wherein R.sup.1 is 2-pyridyl, 3-pyridyl or 4-pyridyl are disclosed as useful as anthelmintics against a broad spectrum of helminths. Processes for making the active compounds and novel intermediates useful therein are also disclosed.

REFERENCES:
patent: 3657267 (1972-04-01), Van Gelder et al.
Van Gelder et al., Chem. Abstracts, vol. 74(19), 100,047s, May 10, 1971.
Burger, Medicinal Chemistry, Second Edition, pp. 78-79, RS 403 B.8 1960 C.7.

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