Anthelmintic milbemycin analogs of novel microorganisms

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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549264, A61K 31365, C07D31500

Patent

active

052908046

ABSTRACT:
There is disclosed a series of macrolides isolated from the fermentation broth of microorganisms identified as MA-6825, MA-6864 and MA-6865. The structure of the novel compounds isolated from the microorganisms is presented based upon analytical studies. The compounds are highly potent antiparasitic, insecticidal, and anthelmintic agents and are related to the class of macrolides known as milbemycins. Compositions for such uses are also disclosed.

REFERENCES:
patent: 3950360 (1973-09-01), Aoki et al.
patent: 4778809 (1988-10-01), Maienfisch et al.
Shirling et al., International J. Systematic Bacteriology, 16, pp. 313-340, Jan. 1986.
Kurtzman et al., International J. Systematic Bacteriology, 30, pp. 208-216, Jan. 1980.

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