Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1988-10-18
1991-05-14
Raymond, Richard L.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
549264, C07D493222, A61K 3135
Patent
active
050156624
ABSTRACT:
There are disclosed new compounds with significant antiparasitic activity which are prepared by fermenting compounds identified as LL-F28249 in a novel microorganism identified as Streptomyces avermitilis MA-5542. The LL-F28249 compounds are modified by the microorganism by hydroxylation of the 25-position terminal methyl group. The compounds are significant antiparasitic and anthelmintic agents and compositions for that use are also disclosed.
REFERENCES:
patent: 4666937 (1987-05-01), Goegelmann et al.
patent: 4831016 (1989-05-01), Mrozik et al.
DiPrima Joseph F.
Merck & Co. , Inc.
Raymond Richard L.
Rose David L.
Russell Mark W.
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