Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1991-09-10
1992-11-17
Berch, Mark L.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
435119, 544350, C07D49122, A61K 31495
Patent
active
051643898
ABSTRACT:
There are disclosed new compound with significant antiparasitic activity which are prepared by fermenting the compounds paraherquamide or dihydroparaherquamide in a novel microorganism identified as Cunninghamella blakesleeana MF-4415. The compounds are best realized in the following structural formulae: ##STR1## wherein A is either a single or a double bond. The paraherquamide compound is modified by the microorganism by ring hydroxylation or ketonization. The compounds are significant antiparasitic and anthelmintic agents and compositions for that use are also disclosed.
REFERENCES:
Blizzard, Chem Abs 111, 7655m (1989).
Yamazaki et al Tetrahedron Letters 22 135-136 (1981).
Blizzard, J. Org. Chem. 54, 2657 (1989).
Berch Mark L.
DiPrima Joseph F.
Merck & Co. , Inc.
Rose David L.
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