Prosthesis (i.e. – artificial body members) – parts thereof – or ai – Implantable prosthesis – Ligament or tendon
Patent
1998-02-12
2000-05-16
Isabella, David J.
Prosthesis (i.e., artificial body members), parts thereof, or ai
Implantable prosthesis
Ligament or tendon
623 16, 623 66, A61F 208
Patent
active
060631201
ABSTRACT:
The invention provides an article of manufacture comprising a substantially non-immunogenic ligament or tendon heterografts for implantation into humans. The invention further provides a method for preparing an ligament heterograft by removing at least a portion of an ligament from a non-human animal to provide a heterograft; washing the heterograft in saline and alcohol; subjecting the heterograft to at least one treatment selected from the group consisting of exposure to ultraviolet radiation, immersion in alcohol, ozonation, freeze/thaw cycling, and optionally to chemical crosslinking. In accordance with the invention the heterograft has substantially the same mechanical properties as the native xenogeneic ligament.
REFERENCES:
patent: 4034418 (1977-07-01), Jackson et al.
patent: 4344193 (1982-08-01), Kenny
patent: 4400833 (1983-08-01), Kurland
patent: 4502161 (1985-03-01), Wall
patent: 4597266 (1986-07-01), Entrekin
patent: 4609627 (1986-09-01), Goldstein
patent: 4627853 (1986-12-01), Campbell et al.
patent: 4642120 (1987-02-01), Nevo et al.
patent: 4678470 (1987-07-01), Nashef et al.
patent: 4755593 (1988-07-01), Lauren
patent: 4776853 (1988-10-01), Klement et al.
patent: 4789663 (1988-12-01), Wallace et al.
patent: 4801299 (1989-01-01), Brendel et al.
patent: 4846835 (1989-07-01), Grande
patent: 4880429 (1989-11-01), Stone
patent: 4932973 (1990-06-01), Gendler
patent: 5007934 (1991-04-01), Stone
patent: 5067962 (1991-11-01), Campbell et al.
patent: 5071741 (1991-12-01), Brockbank
patent: 5078744 (1992-01-01), Chvapil
patent: 5092894 (1992-03-01), Kenny
patent: 5116374 (1992-05-01), Stone
patent: 5131850 (1992-07-01), Brockbank
patent: 5158574 (1992-10-01), Stone
patent: 5160313 (1992-11-01), Carpenter et al.
patent: 5171273 (1992-12-01), Silver et al.
patent: 5171322 (1992-12-01), Kenny
patent: 5171660 (1992-12-01), Carpenter et al.
patent: 5192312 (1993-03-01), Orton
patent: 5216126 (1993-06-01), Cox et al.
patent: 5306304 (1994-04-01), Gendler
patent: 5306311 (1994-04-01), Stone et al.
patent: 5358525 (1994-10-01), Fox et al.
patent: 5507810 (1996-04-01), Prewett et al.
patent: 5613982 (1997-03-01), Goldstein
Rodrigo et al., Clinical Orthopedics and Related Research, 134:342-349 (1978).
Sengupta et al., The Journal of Bone and Joint Surgery, 56B:167-177 (1974).
Webber et al., Journal of Orthopedic Research, 3:36-42 (1985).
Rubak et al., Acta Orthop. Scand, 53:181-186 (1982).
Engkvist, Ove, Scand. J. Plast. Reconstr. Surg., 13:361-369 (1982).
Collins et al., Xenotransplantation, Characterization of Porcine Endothelial Cell Determinants Recognized by Human Natural Antibodies, 1:36-46 (1994).
Satake et al., Xenotransplanation, Limited Specificity of Xenoantibodies In Diabetic Patients Transplanted With Fetal Porcine Islet Cell Clusters. Main Antibody Reactivity Against .alpha.-linked Galactose-Containing Epitopes, 1:89-101 (1994).
LaVecchio et al., Transplantation, Enzymatic Removal of Alpha-Galactosyl Epitopes From Porcine Endothelial Cells Diminishes The Cytotoxic Effect of Natural Antibodies, 60:841-847.
Cotterell et al., Transplantation, The Humoral Immune Response in Humans Following Cross-Perfusion of Porcine Organs, 60:861-868 (1955).
Galili, Immunology Today, 14:480-482 (1993).
Elves et al., An Investigation Into The Immunogenicity of Various Components of Osteoarticular Grafts, The British Journal of Experimental Pathology, 55:344-351 (1974).
LandOfFree
Anterior cruciate ligament heterograft does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Anterior cruciate ligament heterograft, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Anterior cruciate ligament heterograft will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-255025