Chemistry: analytical and immunological testing – Lipids – triglycerides – cholesterol – or lipoproteins
Patent
1995-06-05
1996-08-13
Bhat, Nina
Chemistry: analytical and immunological testing
Lipids, triglycerides, cholesterol, or lipoproteins
514 78, G01N 3392
Patent
active
055455662
ABSTRACT:
An antemortem diagnostic test for neurodegenerative disease, particularly Alzheimer's disease, involves the collection of a sample of bodily fluid; the analysis of the concentration of neuronal membrane phospholipids and phospholipid metabolites, or the ratio of a phospholipid to its metabolite, in the sample; and the correlation of the concentration or the ratio to the corresponding value from control samples. The method can be used to determine the presence or the possibility that an individual can develop a neurodegenerative disease, such as Alzheimer's disease; to follow the course of neurodegenerative disease in an individual; and to validate the efficacy of a drug used to treat a neurodegenerative disease.
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Growden John H.
Nitsch Roger M.
Wurtman Richard J.
Bhat Nina
Massachusetts Institute of Technology
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