Antagonists, their preparation and use

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

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514255, 514292, 5142282, 544126, 544361, 544 60, 546 85, 546 86, 546 87, A61K 31445, A61K 31535

Patent

active

057835756

ABSTRACT:
The present invention relates to therapeutically active non competitive antagonists, acting selectively at the metabotropic glutamate receptor. The novel compounds are useful in treating diseases in the central nervous system by modulating synaptic transmission via the metabotropic glutamate receptor.

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Chemical Abstracts, JP 72 36757, vol. 77, p. 445 (1972).
Kanbe et al., Biosci. Biotech. Biochem., vol. 57, No. 4, pp. 632-635 (1993) .

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