Antagonists of prostaglandin D2 receptors

Organic compounds -- part of the class 532-570 series – Organic compounds – Carboxylic acids and salts thereof

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C562S429000, C562S430000, C560S011000, C560S012000, C560S015000, C560S016000

Reexamination Certificate

active

08071807

ABSTRACT:
Described herein are compounds that are antagonists of PGD2receptors. Also described are pharmaceutical compositions that include the compounds described herein, and methods of using such antagonists of PGD2receptors, alone or in combination with other compounds, for treating respiratory, cardiovascular, and other PGD2-dependent or PGD2-mediated conditions or diseases.

REFERENCES:
patent: 5334598 (1994-08-01), Bagley et al.
patent: 5668176 (1997-09-01), Bagley et al.
patent: 5827868 (1998-10-01), Misra et al.
patent: 6429213 (2002-08-01), Xue et al.
patent: 6617351 (2003-09-01), Arnold et al.
patent: 6858626 (2005-02-01), Xue et al.
patent: 6884593 (2005-04-01), Hirai et al.
patent: 7005440 (2006-02-01), Jayyosi et al.
patent: 7144913 (2006-12-01), Wang et al.
patent: 7321001 (2008-01-01), Fu et al.
patent: 2001/0047027 (2001-11-01), Labelle et al.
patent: 2005/0154044 (2005-07-01), Beaulieu et al.
patent: 2005/0272756 (2005-12-01), Leblanc et al.
patent: 2006/0100425 (2006-05-01), Bennani et al.
patent: 2006/0106081 (2006-05-01), Bennani et al.
patent: 2007/0155726 (2007-07-01), Arnaiz et al.
patent: 2008/0085891 (2008-04-01), Fu et al.
patent: 2008/0167378 (2008-07-01), Fukatsu et al.
patent: 2008/0306109 (2008-12-01), Hynd et al.
patent: 2009/0048238 (2009-02-01), Aebi et al.
patent: 2009/0186923 (2009-07-01), Armer et al.
patent: 2009/0197959 (2009-08-01), Hutchinson et al.
patent: 2010/0004331 (2010-01-01), Hutchinson et al.
patent: 2010/0173313 (2010-07-01), Bain et al.
patent: 2011/0039852 (2011-02-01), Hutchinson et al.
patent: 2011/0098352 (2011-04-01), Hutchinson et al.
patent: 2011/0144160 (2011-06-01), Hutchinson et al.
patent: 1170594 (2002-01-01), None
patent: 2461629 (2010-05-01), None
patent: 2004-182657 (2004-07-01), None
patent: WO-95-03044 (1995-02-01), None
patent: WO-99-11605 (1999-03-01), None
patent: WO-99-65867 (1999-12-01), None
patent: WO-2004-058164 (2004-07-01), None
patent: WO-2004-096777 (2004-11-01), None
patent: WO-2005-040114 (2005-05-01), None
patent: WO-2005-044260 (2005-05-01), None
patent: WO-2005-051373 (2005-06-01), None
patent: WO-2005-105727 (2005-10-01), None
patent: WO-2006-005909 (2006-01-01), None
patent: WO-2006-052798 (2006-05-01), None
patent: WO-2006-125596 (2006-11-01), None
patent: WO-2007-037187 (2007-04-01), None
patent: WO-2007-039736 (2007-04-01), None
patent: WO-2007-068894 (2007-06-01), None
patent: WO-2008-024746 (2008-02-01), None
patent: WO-2008-137027 (2008-11-01), None
patent: WO-2008-154642 (2008-12-01), None
patent: WO-2009-003861 (2009-01-01), None
patent: WO-2009-044147 (2009-04-01), None
patent: WO-2009-063202 (2009-05-01), None
patent: WO-2009-063215 (2009-05-01), None
patent: WO-2009-102893 (2009-08-01), None
patent: WO-2009-145989 (2009-12-01), None
patent: WO-2010-003120 (2010-01-01), None
patent: WO-2010-003127 (2010-01-01), None
patent: WO-2010-039977 (2010-04-01), None
patent: WO-2010-042652 (2010-04-01), None
patent: WO-2010-057118 (2010-05-01), None
patent: WO-2011-014587 (2011-02-01), None
patent: WO-2011-014588 (2011-02-01), None
Arima and Fukuda, “Prostaglandin D2 Receptors DP and CRTH2 in the Pathogenesis of Asthma,” Curr. Mol. Med. 8:365-375 (2008).
Hata and Breyer, “Pharmacology and signaling of prostaglandin receptors: Multiple roles in inflammation and immune modulation,” Pharmacol. Ther. 103:147-166 (2004).
Kostenis and Ulven, “Emerging roles of DP and CRTH2 in allergic inflammation,” Trends Mol. Med. 12(4):148-158 (2006).
Medina and Liu, “PGD2 Antagonists,” Annual Reports Med. Chem. 41:221-235 (2006).
Pettipher et al., “Antagonism of the prostaglandin D2 receptors DP1 and CRTH2 as an approach to treat allergic diseases,” Nature Reviews/Drug Discovery 6:313-325 (2007).
Science IP Structure Search dated Mar. 20, 2008.
Tirouvanziam et al., “Profound functional and signaling changes in viable inflammatory neutrophils homing to cystic fibrosis airways,” PNAS 105(11):4335-4339 (2008).
Ulven and Kostenis, “Targeting the Prostaglandin D2 Receptors DP and CRTH2 for Treatment of Inflammation,” Curr. Topics Med. Chem. 6:1427-1444 (2006).
GB 0911563.5 Search Report dated Sep. 28, 2009.
PCT/US09/049621 ISR and Written Opinion dated Mar. 15, 2010.
PCT/US09/049631 ISR and Written Opinion dated Feb. 24, 2010.
Crosignani et al., “Discovery of a new class of potent, selective, and orally bioavailable CRTH2(DP2) receptor antagonists for the treatment of allergic inflammatory diseases” J Med Chem 51:2227-2243 (2008).
Evans et al., “Seeing the future of bioactive lipid drug targets,” Nature Chem Biol 6:476-479 (2010).
Kim et al., “Regulation of Immune Cells by Eicosanoid Receptors,” TheScientificWorld Journal 7:1307-1328 (2007).
Ly and Bacon, “Small-molecule CRTH2 antagonists for the treatment of allergic inflammation: an overview,” Exp Opin Invest Drugs 14:769 (2005).
Pettipher et al., “The roles of the prostaglandin D(2) receptors DP(1) and CRTH2 in promoting allergic responses,” Br J Pharmacol 153:S191 (2008).
Pettipher et al., “Antagonists of the prostaglandin D2 receptor CRTH2,” Drug News Perspect 21:317-322 (2008).
Sandig et al., “Contrary prostaglandins: the opposing roles of PGD2 and its metabolites in leukocyte function,” J Leukocyte Biology 81:372-382 (2007).
Scott et al., “Discovery and optimization of a biphenylacetic acid series of prostaglandin D2 receptor DP2 antagonists with efficacy in a murine model of allergic rhinitis,” Bioorg Med Chem Ltrs (2011), doi: 10.1016fj.bmc1.2011.01.024.
Srinivas et al., “Biaryl amino acid templates in place of D-Pro-L-Pro in cyclic beta-hairpin cationic antimicrobial peptidomimetics,” Organic & Biomolecular Chemistry 5(19):3100-3105 (2007).
Stearns et al., “Novel tricyclic antagonists of the prostaglandin D2 receptor DP2 with efficacy in a murine model of allergic rhinitis,” Bioorg Med Chem Ltrs 19:4647-4651 (2009).
Stebbins et al., “DP2 Receptor Antagonists: Novel Therapeutic Target for COPD,” Mol Cell Pharmacol 2(3):89-96 (2010).
Stebbins et al., “Pharmacological Blockade of the DP2 Receptor Inhibits Cigarette Smoke-Induced Inflammation, Mucus Cell Metaplasia, and Epithelial Hyperplasia in the Mouse Lung,” J Pharmacol Exp Ther 332(3):764-775 (2010).
Stebbins et al., “Therapeutic efficacy of AM156, a novel prostanoid DP2 receptor antagonist, in murine models of allergic rhinitis and house dust mite-induced pulmonary inflammation,” Eur J Pharmacol 638:142-149 (2010).
Stock et al., “Sodium [2′-[(cyclopropanecarbonyl-ethyl-amino)-methyl]-4′-(6-ethoxy-pyridin-3-yl)-6-methoxy-biphenyl-3-yl]-acetate (AM432): A potent, selective prostaglandin D2 receptor antagonist,” Bioorg Med Chem Ltrs 21:1036-1040 (2011).
Takeshita et al., “CRTH2 is a prominent effector in contact hypersensitivity-induced neutrophil inflammation,” Intl Immunol 16(7):947,959 (2004).
Ulven et al., “Minor Structural Modifications Cover the Dual TP/CRTH2,” J Med Chem 48(4):897-900 (2005).
EP09709954.3 Search Report mailed Feb. 21, 2011.
PCT/US09/64630 Search Report and Written Opinion mailed Jul. 19, 2010.
PCT/US09/59891 Search Report and Written Opinion mailed May 24, 2010.
PCT/US09/59256 Search Report and Written Opinion mailed Jun. 21, 2010.
PCT/US09/38291 Search Report and Written Opinion mailed Nov. 27, 2009.
PCT/US09/33961 Search Report mailed Aug. 11, 2009.
PCT/US09/33961 IPER and Written Opinion mailed Aug. 26, 2010.
PCT/US10/43599 Search Report and Written Opinion mailed Apr. 28, 2011.
PCT/US10/43598 Search Report and Written Opinion mailed Apr. 22, 2011.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Antagonists of prostaglandin D2 receptors does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Antagonists of prostaglandin D2 receptors, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Antagonists of prostaglandin D2 receptors will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-4256920

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.