Antagonists of LHRH

Details Antagonists of LHRH Antagonists of LHRH

1995-04-28

1997-08-12

Tsang, Cecilia J.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

8 to 10 amino acid residues in defined sequence

530313, C07K 700, C07K 706, A61K 3800

Patent

active

056567278

ABSTRACT:
LHRH analogs and congeners with high water solubility have been synthesized. These new analogs had 0%-100% antiovulatory activity at a 0.5 .mu.g dosage and 0%-80% at 0.25 .mu.g. The ED.sub.50 for histamine release was 30.5 .mu.g/ml->300 .mu.g/ml.

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