Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...
Patent
1995-02-22
1998-08-18
Caputa, Anthony C.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Blood proteins or globulins, e.g., proteoglycans, platelet...
4241581, 435326, 435328, 435335, 435346, 435352, C07K 1600, C12N 512, C12N 520, A61K 39395
Patent
active
057959668
ABSTRACT:
Antagonists of mammalian interleukin-15 ("IL-15") are disclosed and include muteins of IL-15 and modified IL-15 molecules that are each capable of binding to the IL-15R.alpha.-subunit and that are incapable of transducing a signal through either the .beta.- or .gamma.-subunits of the IL-15 receptor complex. Also included are monoclonal antibodies against IL-15 that prevent IL-15 from effecting signal transduction through either the .beta.- or .gamma.-subunits of the IL-15 receptor complex. Methods of treating various disease states are disclosed, including treating allograft rejection and graft-versus-host disease.
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Grabstein et al. Science 264:965-8 1994.
Carson et al. J Exp Med. 180: 1395-1403 1994.
Armitage et al. J. Immunol 154: 483-490 1995.
Harlow et al. Antibodies, A Laboratory Manual Cold Spring Harbor Lab, 1988, pp. 285-286.
Grabstein Kenneth H.
Paxton Raymond J.
Pettit Dean K.
Caputa Anthony C.
Malaska Stephen L.
Navarro Mark
Wight Christopher L.
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