Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Lymphokines – e.g. – interferons – interlukins – etc.
Patent
1997-04-25
1999-12-14
Mertz, Prema
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Lymphokines, e.g., interferons, interlukins, etc.
536 231, 536 234, 536 235, 435 6952, 435 697, 435 712, 435471, 435325, 4352523, 4353201, C07K 1454, C12N 1524
Patent
active
060019735
ABSTRACT:
Disclosed herein are mutant IL-15 polypeptides and methods for using these polypeptides to modulate the immune response in a patient.
REFERENCES:
patent: 5011684 (1991-04-01), Strom
patent: 5116964 (1992-05-01), Capon et al.
patent: 5262522 (1993-11-01), Gearing
Cunningham et al, Science vol. 244, pp. 1081-1085, 1989.
George et al. Micromolecular Sequencing & Synthesis, Selected methods and applications. Alan R. Liss Inc, Ch 12, pp. 127-149, 1988.
Pettit et al., "Polyethylene Glycol Conjugation to Lysine Residues of Recombinant IL-15 Generates a Specific IL-15 Antagonist", Pro. of the Int. Symp. on Cont. Release Bioactive Materials; 22:496/497 (1995).
Giri et al., "IL-15, A Novel T Cell Growth Factor That Shares Activities and Receptor Components with IL-2", J. Leukocyte Biology, 57:763-766 (1995).
Blanar et al., "Interaction Cloning: Identification of a Helix-Loop-Helix Zipper Protein That Interacts with c-Fos", Science 256:1014-1018 (1992).
Chae et al., "Mutant IL-15 Protein Exerting Antagonistic Effects on IL-15 Triggered Cell Proliferation", J. American Society of Nephrology 7:1654 (1996).
Anderson et al., Functional Characterization of the Human Interleukin-15 Receptor . . . , J. Bio. Chem., 270:29862-29869, (1995).
Armitage et al., IL-15 Has Stimulatory Activity for the Induction of B Cell Proliferation and Differentiation, J. Immunology, 154:483-490 (1995).
Bamford et al., The interleukin (IL) 2 receptor .beta. chain is shared by IL-2 and a cytokine, provisionally designated IL-T . . . , Proc. Nat. Acad. Sciences 91:4940-4944 (1994).
Brekke et al., Structure-Function Relationships of Human IgG, The Immunologist 2:125-130 (1994).
Burton et al., A lymphokine, provisionally designated interleukin T and produced by a human adult T-cell leukemia line . . . , Proc. Nat. Acad. Sciences 91:4935-4939 (1994).
Carson et al., Interleukin (IL) 15 Is a Novel Cytokine That Activates Human Natural Killer Cells via Components of the IL-2 Receptor, J. Exper. Medicine 180:1395-1403 (1994).
Chae et al., Distribution of IL-15 Receptor a-Chains on Human Peripheral Blood Mononuclear Cells and Effect of . . . , American Association of Immunologists (1996).
Giri et al., Identification and cloning of a novel IL-15 binding protein that is structurally related to . . . , EMBO Journal 14:3654-3663 (1995).
Giri et al., Utilization of the .beta. and .gamma. chains of the IL-2 receptor by the novel cytokine IL-15, EMBO Journal 13:2822-2830 (1994).
Grabstein et al., Cloning of a T Cell Growth Factor That Interacts . . . , Science 264:965-968 (1994).
Hatakeyama et al., A Restricted Cytoplasmic Region of IL-2 Receptor . . . , Cell 59:837-845 (1989).
LeClair et al., The p50 subunit of NF-.kappa.B associates with the NF-IL6 transcription factor, Proc. Nat. Acad. Sciences 89:8145-8149 (1992).
Lin et al., The Role of Shared Receptor Motifs and Common Stat Proteins in the Generation of Cytokine . . . , Immunity 2:331-339 (1995).
Maslinski et al., Interleukin-2 (IL-2) Induces Tyrosine Kinase-dependent Translocation of Active . . . , J. Biological Chemistry 267:15281-15284 (1992).
Maslinski et al., Intoxication of high affinity IL-2 receptor positive thymocytes blocks early stages of T cell maturation, International Immunology 4:509-517 (1992).
Morrison et al., Structural Determinants of Human IgG Function, The Immunologist 2:119-124 (1994).
Nickerson et al., Prolonged Islet Allograft Acceptance in the Absence of Interleukin 4 Expression; Transplant Immunology, 4:81-85 (1996).
Pettit et al., Structure-Function Studies of Interleukin 15 using Site-specific Mutagenesis, Polyethylene Glycol . . . , J. Biological Chemistry, 2312-2318 (1997).
Remillard et al., Interleukin-2 Receptor Regulates Activation of Phosphatidylinositol 3-Kinase. Journal of Biological Chemistry 266:14167-14170 (1991).
Stevens et al., Interleukin-15 signals T84 colonic epithalial cells . . . , The American Physiological Society (1997).
Maslinski Wlodzimierz
Strom Terry B.
Beth Israel Deaconess Medical Center
Mertz Prema
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