Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,... – Structurally-modified antibody – immunoglobulin – or fragment...
Reexamination Certificate
2011-03-15
2011-03-15
Spector, Lorraine (Department: 1647)
Drug, bio-affecting and body treating compositions
Immunoglobulin, antiserum, antibody, or antibody fragment,...
Structurally-modified antibody, immunoglobulin, or fragment...
C424S135100, C424S145100, C530S351000, C530S387300, C530S388230, C435S069520, C435S069700
Reexamination Certificate
active
07906117
ABSTRACT:
The present invention is directed to therapeutic methods using antibodies and fragments thereof having binding specificity for IL-6 to prevent or treat cachexia, fever, weakness and/or fatigue in a patient in need thereof. In preferred embodiments these patients will comprise those exhibiting (or at risk of developing) an elevated serum C-reactive protein level. In another preferred embodiment, the patient's survivability or quality of life will preferably be improved.
REFERENCES:
patent: 5468607 (1995-11-01), Revel et al.
patent: 5468608 (1995-11-01), Revel et al.
patent: 5468609 (1995-11-01), Revel et al.
patent: 5541312 (1996-07-01), Revel et al.
patent: 5545623 (1996-08-01), Matsumori
patent: 5554513 (1996-09-01), Revel et al.
patent: 5556947 (1996-09-01), Bock et al.
patent: 5559012 (1996-09-01), Brailly et al.
patent: 5618700 (1997-04-01), Novick et al.
patent: 5621077 (1997-04-01), Novick et al.
patent: 5627052 (1997-05-01), Schrader
patent: 5646005 (1997-07-01), Kudsk
patent: 5670373 (1997-09-01), Kishimoto
patent: 5707624 (1998-01-01), Nickoloff et al.
patent: 5795965 (1998-08-01), Tsuchiya et al.
patent: 5817790 (1998-10-01), Tsuchiya et al.
patent: 5854398 (1998-12-01), Chang et al.
patent: 5856135 (1999-01-01), Tsuchiya et al.
patent: 5866689 (1999-02-01), Kishimoto et al.
patent: 5882872 (1999-03-01), Kudsk
patent: 5888510 (1999-03-01), Kishimoto et al.
patent: 5888511 (1999-03-01), Skurkovich et al.
patent: 6074636 (2000-06-01), Nichols
patent: 6083501 (2000-07-01), Miyata et al.
patent: 6086874 (2000-07-01), Yoshida et al.
patent: 6121423 (2000-09-01), Tsuchiya et al.
patent: 6231536 (2001-05-01), Lentz
patent: 6235281 (2001-05-01), Stenzel et al.
patent: 6261560 (2001-07-01), Tsujinaka et al.
patent: 6306393 (2001-10-01), Goldenberg
patent: 6395498 (2002-05-01), Tartaglia et al.
patent: 6399054 (2002-06-01), Casorati et al.
patent: 6407218 (2002-06-01), Tamarkin et al.
patent: 6419944 (2002-07-01), Tobinick
patent: 6528051 (2003-03-01), Tamarkin et al.
patent: 6551592 (2003-04-01), Lindhofer et al.
patent: 6723319 (2004-04-01), Ito et al.
patent: 6939547 (2005-09-01), Aoki et al.
patent: 6989244 (2006-01-01), Tsuchiya et al.
patent: 6994853 (2006-02-01), Lindhofer et al.
patent: 7018632 (2006-03-01), Lindhofer et al.
patent: 7108981 (2006-09-01), Aoki et al.
patent: 7235365 (2007-06-01), Aoki et al.
patent: 7261894 (2007-08-01), Sims et al.
patent: 7282567 (2007-10-01), Goldenberg et al.
patent: 7291721 (2007-11-01), Giles-Komar et al.
patent: 7320792 (2008-01-01), Ito et al.
patent: 7374756 (2008-05-01), Aoki et al.
patent: 7468184 (2008-12-01), Sato et al.
patent: 7479543 (2009-01-01), Tsuchiya et al.
patent: 7482436 (2009-01-01), Sugimura et al.
patent: 7504106 (2009-03-01), Skurkovich et al.
patent: 7504256 (2009-03-01), Ogawa et al.
patent: 7534427 (2009-05-01), Goldenberg et al.
patent: 7560112 (2009-07-01), Chen et al.
patent: 7582298 (2009-09-01), Stevens et al.
patent: 7611857 (2009-11-01), Medlock et al.
patent: 7612182 (2009-11-01), Giles-Komar et al.
patent: 7622555 (2009-11-01), Davids et al.
patent: 7662378 (2010-02-01), Goldenberg et al.
patent: 7695716 (2010-04-01), Drachman et al.
patent: 7727528 (2010-06-01), Adcock
patent: 7790463 (2010-09-01), Mor et al.
patent: 2001/0001663 (2001-05-01), Kishimoto et al.
patent: 2003/0229030 (2003-12-01), Theoharides
patent: 2004/0001831 (2004-01-01), Rottman et al.
patent: 2004/0028681 (2004-02-01), Ito et al.
patent: 2004/0071706 (2004-04-01), Ito et al.
patent: 2004/0115197 (2004-06-01), Yoshizaki et al.
patent: 2005/0043517 (2005-02-01), Giles-Komar et al.
patent: 2005/0118652 (2005-06-01), Lee et al.
patent: 2005/0130230 (2005-06-01), Davalos et al.
patent: 2005/0142635 (2005-06-01), Tsuchiya et al.
patent: 2006/0039857 (2006-02-01), Adcock
patent: 2006/0039927 (2006-02-01), Aoki et al.
patent: 2006/0078532 (2006-04-01), Omoigui
patent: 2006/0078533 (2006-04-01), Omoigui
patent: 2006/0134113 (2006-06-01), Mihara
patent: 2006/0159675 (2006-07-01), Jiao et al.
patent: 2006/0165696 (2006-07-01), Okano et al.
patent: 2006/0171943 (2006-08-01), Comeau et al.
patent: 2006/0210563 (2006-09-01), Lopez et al.
patent: 2006/0240012 (2006-10-01), Sugimura et al.
patent: 2006/0251653 (2006-11-01), Okuda et al.
patent: 2006/0275294 (2006-12-01), Omoigui
patent: 2006/0281130 (2006-12-01), Bock et al.
patent: 2006/0292147 (2006-12-01), Yoshizaki et al.
patent: 2007/0005261 (2007-01-01), Serena et al.
patent: 2007/0015197 (2007-01-01), Aoki et al.
patent: 2007/0036785 (2007-02-01), Kishimoto et al.
patent: 2007/0036788 (2007-02-01), Sheriff et al.
patent: 2007/0048306 (2007-03-01), Giles-Komar et al.
patent: 2007/0098714 (2007-05-01), Nishimoto et al.
patent: 2007/0134242 (2007-06-01), Nishimoto et al.
patent: 2007/0243162 (2007-10-01), Aoki et al.
patent: 2007/0243189 (2007-10-01), Yoshizaki et al.
patent: 2007/0280945 (2007-12-01), Stevens et al.
patent: 2008/0124325 (2008-05-01), Ito et al.
patent: 2008/0260687 (2008-10-01), Aoki et al.
patent: 2009/0022719 (2009-01-01), Mihara et al.
patent: 2009/0035281 (2009-02-01), Savino et al.
patent: 2009/0181029 (2009-07-01), Okuda et al.
patent: 2009/0311718 (2009-12-01), Fukushima et al.
patent: 2010/0129357 (2010-05-01), Garcia-Martinez et al.
patent: 2010/0150829 (2010-06-01), Garcia-Martinez et al.
patent: 0484470 (1992-06-01), None
patent: 2004016377 (2004-12-01), None
Kodituwakku et al., “Isolation of antigen-specific B cells,” Immunology and Cell Biology (2003) 81, 163-170.
Steenbakkers et al., “Efficient Generation of Monoclonal Antibodies from Preselected Antigen-Specific B Cells”, Molecular Biology Reports 19: 125-134, (1994).
European Search Report dated Jul. 20, 2009.
Simonsson, et al., Single, Antigen-Specific B Cells Used to Generate Fab Fragments Using CD40-Mediated Amplification or Direct PCR Cloning, Biotechniques, Informa Life Sciences Publishing, vol. 18, No. 5, May 1, 1995, pp. 862, 864-869, XP000572659.
De Wildt, et al., Isolation and Characterization of Single Anti-U1A-specific B Cells from Autoimmune Patients, Annals Of The New York Academy Of Sciences, vol. 815, Apr. 5, 1997, pp. 440-442, XP002536692.
Weitkamp, et al., Generation of recombinent human monoclonal antibodies to rotavirus from single antigen-specific B cells selected with fluorescent virus-like particles, Journal of Immunological Methods, Elsevier Science Publishers, vol. 275, No. 1-2, Apr. 1, 2003, pp. 223-237, XP004416763.
Dohmen, et al., Production of recombinant Ig molecules from antigen-selected single B cells and restricted usage of Ig-gene segments by anti-D antibodies, Journal of Immunological Methods, Elsevier Science Publishers, vol. 298, No. 1-2, Mar. 1, 2005, pp. 9-20, XP004853233.
Beck et al., The New England Journal of Medicine, Mar. 1994, vol. 330, No. 9 pp. 602-605, Alleviation of Systemic Manifestations of Castleman's Disease by Monoclonal Anti-Interleukin-6 Antibody.
Van Zaanen et al., British Journal of Haemtology, 1998, vol. 102, pp. 783-790, Chimaeric Anti-Interleukin 6 Monoclonal Antibodies in the Treatment of Advanced Multiple Myeloma: A Phase I Dose-Escalating Study.
Election/Restrictions action mail date Aug. 11, 2010, U.S. Appl. No. 12/366,567.
Election Response and Amendment filed Sep. 13, 2010, U.S. Appl. No. 12/366,567.
Election of Species action mail date Mar. 5, 2010, U.S. Appl. No. 12/323,194.
Election Reply and Amendment filed Apr. 5, 2010, U.S. Appl. No. 12/323,194.
Non-Final Office action mail date Jun. 7, 2010, U.S. Appl. No. 12/323,194.
Non-Final Office action mail date Sep. 9, 2010, U.S. Appl. No. 12/391,717.
Election of Species action mail date Jan. 7, 2010, U.S. Appl. No. 12/323,066.
Election Response and Amendment filed Feb. 12, 2010, U.S. Appl. No. 12/323,066.
Non-Final Office action mail date May 7, 2010, U.S. Appl. No. 12/323,066.
Amendment and Response filed Aug. 9, 2010, U.S. Appl. No. 12/323,066.
Election/Restrictions action mail date Jun. 24 2009, U.S. Appl. No. 12/153,612.
Response to Restriction Requirement and Petition for One-Month Extension of Time filed Aug. 24, 2010, U.S. Appl. No. 12/153,612.
Office Comm
Latham John
Litton Mark J.
Schatzman Randall C.
Smith Jeffrey T. L.
AlderBio Holdings LLC
Hunton & Williams LLP
Spector Lorraine
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