Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – 15 to 23 amino acid residues in defined sequence
Patent
1994-02-04
1995-12-12
Warden, Jill
Chemistry: natural resins or derivatives; peptides or proteins;
Peptides of 3 to 100 amino acid residues
15 to 23 amino acid residues in defined sequence
530399, A61K 3810
Patent
active
054750873
ABSTRACT:
Antagonists of GM-CSF are disclosed that comprise antibodies and anti-idiotypic antibodies specific for the carboxyl terminus of GM-CSF. These antagonists are useful for treating various diseases, the symptoms of which are increased by GM-CSF, and for lessening the effects of chemotherapy.
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Gough et al., Molecular Cloning of cDNA Encoding a Murine Haematopoietic Growth Regulator, GM-CSF, Nature 309:763 (1984).
Grantham, Amino Acid Difference Formula to Help Explain Protein Evolution, Science 185:862 (1974).
Gualtieri et al.; GM-CSF Is An Endogenous Regulator of Cell Proliferation in Juvenile Chronic Myelogenous Leukemia, Clin. Res. 36:24A (1988).
Sege et al., Use of Anti-idiotypic Antibodies As Cell-surface Receptor Probes, Proc. Natl. Acad. Sci. USA 75:2443 (1978).
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Scheffler Julie E.
Seelig Gail F.
Trotta Paul P.
Dulak Norman C.
Lukton David
Lunn Paul G.
Nelson James R.
Schering Corporation
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