Antagonists of HMG1 for treating inflammatory conditions

Details Antagonists of HMG1 for treating inflammatory conditions Antagonists of HMG1 for treating inflammatory conditions

2006-06-13

2006-06-13

Kemmerer, Elizabeth (Department: 1649)

Chemistry: analytical and immunological testing

Biospecific ligand binding assay

C435S006120, C435S007100, C435S007210, C424S130100, C424S145100, C530S351000, C530S387100, C530S388220, C530S350000, C514S002600, C536S023500

Reexamination Certificate

active

07060504

ABSTRACT:
There is disclosed a pharmaceutical composition and method for treating sepsis, including septic shock and ARDS (acute respiratory distress syndrome), comprising administering an effective amount of a HMG1 antagonist. There is further disclosed a diagnostic method for monitoring the severity or potential lethality of sepsis or septic shock, comprising measuring the serum concentration of HMG1 in a patient exhibiting or at risk or exhibit sepsis or septic shock symptoms. Lastly, there is disclosed a pharmaceutical composition and method for effecting weight loss or treating obesity, comprising administering an effective amount of HMG1 or a therapeutically active HMG1 fragment.

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