Antagonists of gonadotropin releasing hormone

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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514339, 514381, 514382, 514414, A61K 3144

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active

06077858&

ABSTRACT:
There are disclosed compounds of formula (I) ##STR1## and pharmaceutically acceptable salts thereof which are useful as antagonists of GnRH and as such may be useful for the treatment of a variety of sex-hormone related and other conditions in both men and women.

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Shu et al. Synthesis if a tritiated human growth hormone releasing peptide, Int. J. Pept. Protein Res., vol. 42/3, pp. 432-439, (1993).
CA 124:233030, Bru-Magnieze, et al. (1996).
J. Med, Chem., vol. 32, pp. 2036-2038 (1989), by Clark, et al.

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