Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Lymphokines – e.g. – interferons – interlukins – etc.
Reexamination Certificate
2003-06-03
2009-06-02
Landsman, Robert (Department: 1646)
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Lymphokines, e.g., interferons, interlukins, etc.
C424S085100, C424S185100, C424S198100, C536S023500, C435S069500
Reexamination Certificate
active
07541435
ABSTRACT:
Novel antagonists of CXCR3-binding CXC chemokines, and in particular of human CXCL11, can be obtained by generating mutants of such chemokines in which the binding to glycosaminoglycans (GAGs) is impaired due to non-conservative substitutions of amino acids involved in this interaction. Compounds prepared in accordance with the present invention can be used to block the activity of CXCR3-binding CXC chemokines on CXCR3-expressing cells, thereby providing therapeutic compositions for use in the treatment or prevention of diseases related to excessive activated T cells migration, such as graft rejection and autoimmune diseases, and of diseases needing an increase of vascularization, such as ischemic heart disease.
REFERENCES:
patent: 5656724 (1997-08-01), Daly et al.
patent: 5739103 (1998-04-01), Rollins et al.
patent: 5969093 (1999-10-01), Jacobs et al.
patent: 5977334 (1999-11-01), Ransohoff et al.
patent: 6140064 (2000-10-01), Loetscher et al.
patent: 2002/0018776 (2002-02-01), Hancock
patent: WO 02/04015 (2002-01-01), None
patent: WO 02/43758 (2002-06-01), None
Widney D.P. et al. The murine chemokine CXCL11 (IFN-inducible T cell a-chemoattractant) is an IFN-g- and lipopolysaccharide-inducible glucocorticoid-attenuated response gene expressed in lung and other tissues during endotoxemia. J. Immunol. 2000. vol. 164, p. 6322-6331.
Mickle J.E. et al. Genotype-phenotype relationships in cystic fibrosis. Med. Clin. N. America. 2000, vol. 84, p. 597-607.
Loertscher, P. et al. “The Ligands of CXC Chemokine Receptor 3, I-TAC, Mig, and IP10, Are Natural Antagonists for CCR3”The Journal of Biological Chemistry, Feb. 2, 2001, pp. 2986-2991, vol. 276, No. 5.
Kosco-Vilbois Marie
Proudfoot Amanda
Hissong Bruce D
Landsman Robert
Merck Serono SA
Saliwanchik Lloyd & Saliwanchik
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