Antagonists of chemokine receptors

Details Antagonists of chemokine receptors Antagonists of chemokine receptors

2007-04-10

2007-04-10

Berch, Mark L. (Department: 1624)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

C544S279000, C544S363000, C514S264100, C514S264110

Reexamination Certificate

active

10648677

ABSTRACT:
Compounds are provided which are antagonists of chemokine receptor activity.The compounds thereof have the structureincluding enantiomers, diastereomers, tautomers, pharmaceutically acceptable salts and solvates thereof wherein:A, B, D, E, X and Y are selected from N or C, J and K are C, and at least one of A, B, D, E, X and Y is N;L is selected from O, NH and S, wherein L may be connected to any one of A, B, D, E, J, X, K or Y;M is CH or N;P is a bond or C═O, wherein P is connected to any one of J, X, K or Y;Z is C(═O)GR2or C(H)2GR2; G is O or NH or none, or when Z is C(═O)GR2, G also includes1, 2propylene;n is 0–4;R1is selected from halogen, —CN, —CF3, substituted alkyl, aryl and heteroaryl;R2is a heterocyclyl containing at least one N;R3is selected from halogen, cyano, alkyl, substituted alkyl, aryl, substituted aryl, heteroaryl and substituted heteroaryl, wherein R3is connected to any one of A, B, D and E;R4and R5are H;or R4and R5may be taken together with the atoms to which they are attached to form a ring; andR10is selected from H, alkyl, substituted alkyl, alkenyl, substituted alkenyl;or E and R10may be taken together with the atoms to which they are attached to form a heteroaryl or heterocycloalkyl ring.

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