Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,... – Binds antigen or epitope whose amino acid sequence is...
Patent
1996-05-29
2000-09-05
Hutzell, Paula K.
Drug, bio-affecting and body treating compositions
Immunoglobulin, antiserum, antibody, or antibody fragment,...
Binds antigen or epitope whose amino acid sequence is...
4241411, 4241311, 4241561, 4241741, 5303873, 5303879, 5303887, 530380, 530327, 53038824, C07K 1600, C07K 1618, A61K 39395, A61K 3514
Patent
active
061138991
ABSTRACT:
An antagonist to, or an antibody (Ab) raised against, cpn10 or a recombinant cpn10 with the sequence: GSAGQAFRKFLPLFDRVLVERSAAETVTKGGIMLPEKSQGKVLQATVEAVGSGSKGKGGEIQPVSVKEGDK VLLPEYGGTKVVLDDKDYFLFRDGDILGKYVD is claimed. Also, claimed are: (1) an antagonist or Ab raised against a peptide derived from cpn10, or a peptide with the sequence: Ac-AGQAFRKLPL(C) AGQAFRKFLPLA2 A1AGQAFRKFLPL Ac-A1AGQAFRKFLPL (A1)EKSQGKVLQATA2 A1EKSQGKVLQAT where A1 and A2 are amino acid sequences that may be added to one or both ends of the peptides, and where the peptides may have a single amino acid deletion, addition or substitution; (2) suppressing cellular growth or enhancing immunological activity by admin. of a cpn10 antagonist or anti-cpn10 Ab to a subject; and (3) an assay for measuring anti-cpn10 Ab in a sample by: (a) reacting purified cpn10 with the sample (b) determining the amt. of Ab in the sample by determining the binding between the Ab and cpn10.
USE--The cpn 10 antagonist or Ab can be used to terminate pregnancy, suppressing tumour cell growth or enhancing the immune system.
REFERENCES:
Cavanagh et al., "The Purification of Early-Pregnancy Factor To Homogeneity From Human Platelets and Identification as Caperonin 10", Eur. J. Biochem., vol. 222:551-560, (1994).
Quinn et al., "Effect Of Monoclonal Antibodies To Early Pregnancy Factor (EPF) On The in vivo Growth of Transplantable Murine Tumours", Cancer Immunol. Immunother, vol. 34:265-271, (1992).
Quinn et al., "Monoclonal Anibodies to Early Pregnancy Factor Perturb Tumour Cell Growth", Clin. exp. Immunol., vol. 80:100-108, (1990).
Quinn et al., "Early Pregnancy Factor In Liver Regeneration After Partial Hepatectomy In Rats: Relationship With Chaperonin 10", Hepatology, vol. 20:1294-1302, (1994).
Hartman et al., "Identification Of A Mammalian 10-kDa Heat Shock Protein, A Mitochondrial Chaperonin 10 Homologue Essential For Assisted Folding Of Trimeric Ornithine Transcarbamoylase in vitro", Proc. Natl. Acad. Sci. USA, vol. 89:3394-3398, (1992).
Monzini et al., "Identification And Cloning Of Human Chaperonin 10 Homologue", Biochimica et Biophysica Acta, vol. 1218:478-480, (1994).
Morton et al., "Early Pregnancy Factor", Seminars in Reproductive Endocrinology, vol. 10:72-82, (1992).
Cavanagh Alice Christina
Morton Halle
Bansal Geetha P.
Hutzell Paula K.
The University of Queensland
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