Antagonistic anti-hTNFSF13b human antibodies

Details Antagonistic anti-hTNFSF13b human antibodies Antagonistic anti-hTNFSF13b human antibodies

2008-01-08

2008-01-08

Rawlings, Stephen L. (Department: 1643)

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

Blood proteins or globulins, e.g., proteoglycans, platelet...

C530S351000, C530S387300, C530S388150, C530S388230

Reexamination Certificate

active

07317089

ABSTRACT:
Human monoclonal antibodies that specifically bind to TNFSF13bpolypeptides are disclosed. These antibodies have high affinity for hTNFSF13b(e.g., KD=10−8M or less), a slow off rate for TNFSF13bdissociation (e.g., Koff=10−3sec−1or less) and neutralize TNFSF13bactivity in vitro and in vivo. The antibodies of the invention are useful in one embodiment for inhibiting TNFSF13bactivity in a human subject suffering from a disorder in which hTNFSF13bactivity is detrimental. Nucleic acids encoding the antibodies of the present invention, as well as, vectors and host cells for expressing them are also encompassed by the invention.

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GenBank Accession No. AA682496.
GenBank Accession No. AA166695.
GenBank Accession No. D79690.
GenBank Accession No. R16882.
GenBank Accession No. T87299.
GenBank Accession No. G30081.

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