Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...
Reexamination Certificate
2007-08-28
2007-08-28
Helms, Larry R. (Department: 1643)
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Blood proteins or globulins, e.g., proteoglycans, platelet...
C424S135100, C424S141100
Reexamination Certificate
active
10506743
ABSTRACT:
Human antibodies, preferably recombinant human antibodies that specifically bind to human Fas Ligand (hFasL) are disclosed. These antibodies have high affinity for hFasL, a slow off rate for hFasL dissociation and neutralize a Fas Ligand activity in vitro and in vivo. An antibody of the invention can be a full-length antibody or an antigen-binding portion thereof. The antibodies, or antigen-binding portions, of the invention are useful for neutralizing Fas Ligand activity, e.g., in a human subject suffering from a disorder in which hFas Ligand activity is detrimental. Nucleic acids, vectors and host cells for expressing the recombinant anti-hFasL human antibodies, and the methods for synthesizing the recombinant human antibodies are also encompassed by the invention.
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Eli Lilly and Company
Gussow Anne M.
Helms Larry R.
Martinez Alejandro
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