Antagonistic analogs of GH-RH inhibiting IGF-I and -II

Details Antagonistic analogs of GH-RH inhibiting IGF-I and -II Antagonistic analogs of GH-RH inhibiting IGF-I and -II

1998-11-25

2000-05-02

Moezie, F. T.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

25 or more amino acid residues in defined sequence

530317, 514 9, 514 11, 514 12, 436 64, C07K 764, C07K 700, C07K 1100, A61K 3816, A61K 3825

Patent

active

060574224

ABSTRACT:
There is provided a novel series of synthetic analogs of hGH-RH(1-29) NH.sub.2. These analogs inhibit the activity of endogenous hGH-RH, and therefore prevent the release of growth hormone. The stronger inhibitory potencies of the new analogs, as compared to previously described ones, results from replacement of various amino acids.

REFERENCES:
patent: 5550212 (1996-08-01), Zanandi et al.
patent: 5942489 (1999-08-01), Schally et al.
Zanandi et al, "Synthesis and Biological Activities of Highly Potent Antagonists of Growth Hormone-Releasing Hormone" Proc. Natl. Acad. Sci., USA, vol. 91, pp. 22298-12302, Dec. 1994.

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