Antagonistic analogs of GH RH (2003)

Details Antagonistic analogs of GH RH (2003) Antagonistic analogs of GH RH (2003)

2004-07-26

2008-11-18

Gupta, Anish (Department: 1654)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

C514S002600, C514S009100, C514S010100, C514S011400, C530S324000, C530S317000

Reexamination Certificate

active

07452865

ABSTRACT:
There is provided a novel series of synthetic antagonistic analogs of hGH-RH(1-29)NH2. These analogs inhibit the activity of endogenous hGH-RH on the pituitary GH-RH receptors, and therefore prevent the release of growth hormone. The analogs also inhibit the proliferation of human cancers through a direct effect on the cancer cells. The higher inhibitory potencies of the new analogs, as compared to previously described ones, results from replacement of various amino acids.

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