Drug – bio-affecting and body treating compositions – Solid synthetic organic polymer as designated organic active... – Polymer from ethylenic monomers only
Patent
1996-03-13
1997-11-18
Elliott, George G.
Drug, bio-affecting and body treating compositions
Solid synthetic organic polymer as designated organic active...
Polymer from ethylenic monomers only
424 92, 514 2, 514 12, A61K 4900, A61K 3800, G01N 3100, A61N 3117
Patent
active
056884990
ABSTRACT:
The mechanism of hypertension following acute NO synthase blockade is via endothelin mediated vasoconstriction. Thus, NO appears to inhibit endothelin activity by blocking its expression and not as a chronic direct acting vasodilator. Administration of an endothelin antagonist to a patient in a `normal` physiological state may result in specific regional vasodilation. This treatment finds utility in the treatment of erectile dysfunction.
REFERENCES:
Banting et al., Increased endothelin activity plays a primary role hypertension induced by acute nitric oxide synthase blockade, FASEB Journal v.9 (3) p. A338, Mar. 9, 1995.
Wang et al., Involvement of endothelin-1 in hypoxic pulmonary vasoconstriction in the lamb, Journal of Physiology v.482 (2) pp. 421-434, Jan. 15, 1995.
Teerlink et al., Role of endothelin in the maintenance of blood pressure in concious rats with chronic heart failure, Circulation v.90 (5) pp. 2510-2518, Nov. 1994.
Luscher et al., Pharmacological inhibition of endothelin induced vasoconstriction in man: Focus on calcium channel blockers and endothelin receptor antagonists, Drugs of today v.31 (supple B) pp. 7-17, 1995.
Adams Michael A.
Banting James D.
Heaton Jeremy P.W.
Elliott George G.
Hicks Richard J.
Queen's University at Kingston
Wang Andrew
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