Antacid tablets and processes for their preparation

Details Antacid tablets and processes for their preparation Antacid tablets and processes for their preparation

1976-12-03

1980-10-28

Waddell, Frederick E.

Drug, bio-affecting and body treating compositions

Immunoglobulin, antiserum, antibody, or antibody fragment,...

Monoclonal antibody or fragment thereof

424157, A61K 3310, A61K 3308

Patent

active

042306930

ABSTRACT:
An antacid tablet is prepared which contains a combination of an antacid ingredient, sugar, and fat and which has a hardness requiring no more than 9 pounds peak force to cause a blunt probe to penetrate its surface. Included also are processes for preparing such a tablet in which an antacid ingredient, sugar, and melted fat are mixed, cooled and milled to produce a powdered mixture, and the mixture formed into tablets. Further improvements include using a fine sugar, 90% of which will pass a 200 mesh screen; maintaining the plungers and dies of the tableting machine above the melting point of the fat; and utilizing a limited pressure (50 to 600 pounds per square inch) in the compressing of the tablets. Another feature involves controlling the moisture to within 3 to 10% based on the weight of the tablet.

REFERENCES:
patent: 1889366 (1932-11-01), McGowan
patent: 3253988 (1966-05-01), Scott
patent: 3843778 (1974-10-01), Diamond et al.
Remington's Pharmaceutical Sciences, 13th Ed., (1965), pp. 562-584.

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