Antacid preparation having a prolonged gastric residence time

Details Antacid preparation having a prolonged gastric residence time Antacid preparation having a prolonged gastric residence time

1991-11-13

1993-05-25

Waddell, Frederick E.

Drug, bio-affecting and body treating compositions

Digestive system regulator containing solid synthetic...

424480, 424482, 424682, 424690, 424692, 514819, A61K 3174, A61K 936, A61K 932, A61K 3306, A61K 3314, A61K 3308

Patent

active

052137945

ABSTRACT:
The present invention relates to an antacid preparation having a prolonged gastric residence time, comprising an antacid active substance, calcium polycarbophil and a water-insoluble, anionic polymer.

REFERENCES:
patent: 3555151 (1966-12-01), Kaplan et al.
patent: 4514389 (1985-04-01), Miyata
patent: 4542019 (1985-09-01), Lezdey
patent: 4615697 (1987-10-01), Robinson
patent: 4980175 (1990-12-01), Chavkin et al.
Asher Winkelstein, M.D., Effect of Calcium Polycarbophil (Carbofil) Suspension on Gastrointestinal Transit Time, vol. 6, No. 9, Sep. 1964.
Jian-Mei Gu, Binding of Arcylic Polymers to Mucin/Epithelial Surface-Property Relationships, vol. 5, Issue 1 (1988).
Sau-Hung Spence Leung, The Contribution of Anionic Polymer Structural Features to Mucoadhesion, (1988).

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