Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Food or edible as carrier for pharmaceutical
Reexamination Certificate
1998-03-12
2001-09-04
Page, Thurman K. (Department: 1615)
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Food or edible as carrier for pharmaceutical
C424S464000, C424S465000, C424S484000
Reexamination Certificate
active
06284265
ABSTRACT:
TECHNICAL FIELD
The present invention relates generally to the animal husbandry field and, more particularly, to an antacid formulation adapted for administration to horses.
BACKGROUND OF THE INVENTION
Many horses suffer from excess gastric acid secretions when receiving high grain, low forage diets. This is particularly true of horses under “heavy work” conditions including race training, eventing and polo competitions. It is also true of young horses which are receiving such diets in order to promote growth. A high grain-low forage diet is defined as more than 5 kgs (11 lbs) of concentrate feed per day or a forage to grain ratio of less than 1:1.
As a more detailed example, studies have shown that between 80-90% of racehorses in training have gastric ulcers occur in the fundus, the nonglandular region of the stomach located above the margo plicatus. The fundus consists of squamous epithelial cells that are similar to the tissue found in the esophagus. The cells in the fundus do not have a mucus layer. Further, the fundus cells do not secrete bicarbonate. Accordingly, the only protection these cells have from gastric acid is furnished by saliva which provides a natural buffering effect.
Race horses in training are often fed high grainlow forage diets. Unfortunately, grains and pelleted concentrates have a tendency to increase the production of gastrin: a hormone that stimulates gastric acid production. Often race horses in training are fasted for extended periods of time before a training exercise, workout or race. This fasting has a tendency to reduce saliva production. Thus, race horse management and handling has the unfortunate effect of promoting higher levels of gastric production and lower levels of saliva production. This results in the exposure of the fundus to gastric acid at lower pH levels for longer periods of time without effective buffering from saliva production. As a consequence gastric irritation occurs and often lesions develop. Thus, it should be appreciated that gastric acid is the major cause of ulcers in the fundus region of the stomach.
The present invention relates to an antacid formulation specifically adapted to aid in the reduction of excess gastric acid secretion in horses suffering from this malady.
SUMMARY OF THE INVENTION
It is, accordingly, one object of the present invention to provide antacid formulations for the safe and effective treatment and relief of excess gastric acid secretions.
A further object of the present invention is to provide an antacid formulation particularly effective in reducing excess gastric acid secretions in horses resulting from a high grain-low forage diet.
Still another object of the present invention is to provide a safe and effective method of reducing excess gastric acid secretions and to coat and protect the mucosa from gastric acid irritation in horses.
Other objects and advantages of the present invention will become apparent as the description thereof proceeds.
In satisfaction of the foregoing objects and advantages, there is provided by this invention, an antacid formulation comprising by weight percent:
11.0-45.0% antacid selected from a group consisting of aluminum phosphate, dihydroxy-aluminum-sodium-carbonate, dicalcium phosphate, calcium carbonate and mixtures thereof;
4.0-8.0% oil;
0.02-1.0% antioxidant; and
46.0-84.5% carrier.
More specifically, the antacid formulation includes ethoxyquin as the antioxidant and utilizes a vegetable oil such as soybean oil. Preferably, the carrier utilized is selected from a group consisting of ground wheat, spray dried whey, steam rolled oats and mixtures thereof.
More specifically describing the invention, the antacid formulation includes by weight percent between:
5.0-15.0% aluminum phosphate;
5.0-15.0% dihydroxy-aluminum-sodium-carbonate;
4.0-8.0% soybean oil;
1.0-5.0% dicalcium phosphate;
0-10.0% calcium carbonate;
0.02-1.0% ethoxyquin; and
46.0-84.5% carrier.
Still more specifically, the antacid formulation comprises by weight percent:
10.0% dihydroxy-aluminum-sodium-carbonate;
10.0% aluminum phosphate;
6.0% soybean oil;
2.75% dicalcium phosphate;
0.7% calcium carbonate;
0.1% ethoxyquin; and
70.45% carrier (30.45% ground wheat, 20.0% spray dried whey and 20.0% steam rolled oats).
REFERENCES:
patent: 4327076 (1982-04-01), Puglia
The Merck Index; Eleventh Edition; 1989; Entries 362, 3169, 1699 and 1657.
The Merck Index, 12th edition, 1996, pp. 3794-3795.
Glyer J. Mark
Kaster Richard S.
Lambert David H.
Pagan Joe D.
King and Schickli PLLC
KPL Technologies, Inc.
Page Thurman K.
Pulliam Amy E
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